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Do Peptides Really Work?

Despite the variety of peptides, you should know that they all perform only one important function – they activate DNA. In the simplest and most accessible way, peptides help the cell work in the genes.

Peptide bioregulators help the organs to function correctly without any abnormalities. Therefore, peptides influence will not have a considerable effect if you are still young. Then, closer to old age, you can notice a significant difference in the health of those who use peptides and the rest of the people.

It is in the genes of almost every person to reach the age of over 100 years. Experiments with peptides reliably show that they increase life expectancy by about 30%, approaching as close as possible to the genetic limit.

What are the most famous types of peptides today, and what are their characteristics?

Research on peptides, including with the help of clinical studies, confirms that this class of products has a unique effect and can strengthen or restore health. Therefore, there is a tremendous demand for peptide bioregulators as many want to be healthy and young. Manufacturers began to produce peptides with different compositions, the dosage of the active substance and other parameters. The most famous of them will be listed here.

Cytamines

Although their prevalence cytamines are available in pharmacies in almost every city, these peptide bioregulators are of minimal interest to us. After all, there is very little active substance inside, and at the same time, the price is unreasonably high. Even in the very name of cytamines, part of the word “min” indicates a minimum of the active substance here.

Nevertheless, cytamines undoubtedly work and have a therapeutic/supportive effect.

Effectiveness: 1 out of 10

Peptide Complexes (PCs)

The uniqueness of these peptides is that they are used externally. Who does not want to swallow capsules? There is a solution! Peptide complexes are peptides dissolved in essential oils. It is enough to rub them into your skin simply (usually done on the wrist or forearm).

But each person’s skin is different (permeability), and the amount of active substance in these complexes is meagre. As a result, Peptide Complexes can only be used for maintenance and prevention. The effect here is approximately the same as cytamines, but the price is about 5-7 times lower.

Performance: 2 out of 10

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There is a relatively budget line, but its efficiency is significantly higher:

The composition contains several peptide bioregulators of related systems at once.
In addition to peptides, extracts and essential oils of medicinal plants give an additional effect.
The sublingual method of administration is very successful.

It allows not only to bring the absorption of the peptides closer to 100% but also to make the peptides work immediately after intake.

Cytogens

Breeding animals and obtaining the desired peptides from their organs is costly and complex. Therefore, scientists have invented a new way to bring peptide bioregulators from plant proteins. The resulting peptides have a similar effect to natural peptides and start working much faster.

Cytogens are much cheaper than Havinson’s natural peptides, but their efficiency is only 60-70%. That’s why it makes sense to use them when you need an immediate effect or prevention. There is nothing better than natural peptides for a therapeutic and prophylactic effect.

Performance: 7 out of 10

Peptides Revilab ML

Simply put, Revilab ML is the same as cytogens, but several types in one capsule. For example, Revilab ML 06 contains peptides from the stomach, liver, and pancreas. That is, it affects almost the entire digestive tract. In addition, the composition includes extracts from medicinal plants and other valuable substances.

Cytomaxes do not work so quickly, but their effect lasts a very long time after their use. Therefore, you can use them once every six months. It ensures the continuous action of the peptide bioregulators. If you need the maximum effect of peptides, you need Cytomax! Their disadvantage is that they are much more expensive. The price of the monthly course is about BGN 100, while for a lasting result you should take them between 2 and 4 months.

Cytomaxes are used when the most substantial effect of the peptides is needed. Just think, using just one Vladonix immunity peptide reduces the total incidence of acute respiratory infections (including coronavirus) by about 2.5 times! No multivitamin can even come close to that result.

Performance: 9 out of 10

Linguals (Sublingual peptides)

The recently appeared Lingual Peptides (Sublingual Peptides) are the most effective peptides currently available. Sublingual peptides are the same cytomaxes or cytogens, but in liquid form. They are taken sublingually or dripped into the mouth. Ultimately, which has undeniable advantages. First, they reach the target as quickly as possible and start working in just a few minutes.

Secondly, they can be dosed. Some people complain that they do not feel very comfortable after using peptides in capsules, especially in the first days. It is due to the dosage being too high. There is no such problem under the tongue! Their disadvantage is the higher price. The course of admission will cost more compared to that of cytomaxes. We recommend using lingual peptides if you have problems with the gastrointestinal tract.

Can Anyone Buy Peptides?

If you have read this article, you already know what types of peptides to improve health and quality of life currently exist, what their characteristics are and how effective they are. We hope that now you will be able to independently choose one or another class of peptides, depending on the goal. If you have difficulties or want to get advice on the choice of peptides, then you can always contact us and you will receive a response from a specialist in peptide bioregulation within 24 hours.

Here we take a look at Where to buy peptides are and where to buy peptides for educational and research needs. Research peptides are a new form of chemicals that are being tested to treat various age-related health problems.

Where to Buy Peptides for Research?

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What is a Peptide Sequence?

A region or a sequence, which exhibits a relatively strong affinity to the antibodies used. The antigen as required can be produced using the immunological method known to the person skilled in the art, e.g. the methods described in the literature, see e.g. M. Kast, Immunology of Peptide Synthesis, Springer-Verlag Berlin Heidelberg New York 1992; R. V. Page, Synthesis of Peptides and Proteins, New York, Oxford University Press 1988.

The immunological method known to the person skilled in the art can be adapted for the production of the antigen required. In one embodiment the antigen is a fusion protein that contains the antigen, as well as an antigenic fragment of the protein to be measured, as the antigens to be measured, are often too small to be purified to homogeneity.

The method known to the person skilled in the art comprises the following steps:

a) a host cell is transformed with an expression vector comprising DNA encoding for a polypeptide chain which is known to the person skilled in the art to be immunogenic and which comprises the antigen of interest and/or an antigenic fragment thereof

b) the transformed host cell is cultured under suitable conditions, whereby an amount of the polypeptide chain of interest is produced by the host cell.

How the antigen is produced?

The antigen can be purified from the culture supernatant or from the cell in which it was produced. It uses affinity chromatography, followed by further purification if necessary. In one embodiment, the antigen is a fusion protein, i.e. the antigen is not directly produced in the host cell, but is produced as a part of another protein, which in turn is produced as a part of the antigen.

The expression vector used in the step comprises DNA coding for the first protein. In this case, the method comprises the following steps:

a host cell is transformed with a second expression vector comprising DNA encoding for a fusion protein.
The transformed host cell is cultured under suitable conditions.
The culture supernatant or the cell in which the polypeptide of interest is produced is contacted with an antibody specific for the second protein and an amount of the polypeptide is bound to the antibody.
The bound polypeptide is eluted.
A further purification step is performed.

What is a Polypeptide?

The second protein (e.g. a polypeptide) used in the method described in the second embodiment can be a fusion protein comprising the antigen as its N- or C-terminal portion. In this case, the first protein which is produced as a part of the antigen comprises a peptide sequence. It binds to an antibody specific to the polypeptide. The first protein binds to the antibody when the polypeptide is produced as a part of the fusion protein.

Steps of the method described above in the second embodiment can be repeated to further increase the yield of the polypeptide of interest. However, once the maximum yield is reached, the production of the fusion protein can be terminated. A further embodiment is characterized in that a method for the production of a fusion protein is used which comprises steps above. In this case, the second protein (e.g. a polypeptide) is a fusion protein comprising the antigen as its N- or C-terminal portion.

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The first protein is produced as a part of the fusion protein with a polypeptide which can be purified in a purification step by the use of antibodies, such as monoclonal antibodies, which bind to the polypeptide.

What is a fusion protein?

Preferably, the fusion protein is produced in accordance with the method described above in a). The second protein can be a polypeptide which is present in the culture medium, or it can be a fusion protein comprising the antigen as its N- or C-terminal portion. The antigen can be present at an expression level of from 0.1% to 50% of the total amount of polypeptide in the mixture comprising the fusion protein and culture medium. A preferred embodiment is characterized in that the polypeptide comprises a sequence of from 1 to 5 amino acids, more preferably from 3 to 5 amino acids, most preferably from 3 to 5 amino acids.

What are proteins?

Examples of proteins that can be used as second proteins in the fusion protein according to the invention are polypeptides present in the medium and purification steps, e.g. an N-terminal polyhistidine (His) peptide and a C-terminal Strep II (Streptococcus Typhimurium protein A-II) peptide.

Examples of polypeptides are those which are present in the medium of the bacterial culture. The medium can be a nutrient broth, such as for example a nutrient broth according to EP patent applications having publication numbers 0 689 566 and 0 689 566, which are incorporated herein by reference. The polypeptides can be present in the medium in an amount of from 10 pg/ml to 10 mg/ml, more preferably from 50 pg/ml to 0.5 mg/ml, more preferably from 50 pg/ml

Examples of suitable protein fusion proteins are those having from 6 to 30, e.g. from 12 to 30, amino acid residues. Preferably the protein comprises a sequence of from 6 to 30 amino acids, more preferably of from 12 to 30 amino acids, and most preferably from 15 to 30 amino acids.

The protein fusion proteins of the invention can be prepared according to known techniques. For example, using techniques well known to the person skilled in the art, such as polypeptide coupling, recombinant techniques, or genetic engineering.

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