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According to a Danish study, the best Tesofensine buy online is a drug against obesity works twice as well as all other drugs currently available on the market.
A newly developed active substance aims to satisfy hunger where it arises. Tesofensine suppresses feelings of hunger in the brain, write the researchers led by Arne Astrup from the University of Copenhagen in the journal “Lancet”. Subjects in a study had lost several kilograms.
Marketability is questionable
However, the nutritionist Stephan Bischoff from the University of Hohenheim warned against exaggerated expectations: “This is hopeful news, but it should be treated with great caution,” he said. “A really effective drug without major side effects has often been promised, but the promise has never been kept.” It is not yet certain whether Tesofensin will ever come onto the market.
Results of the “Fat Path Study
In a series of tests, the Danish scientists examined 203 overweight patients who weighed more than 100 kilograms on average. A quarter of the patients received an ineffective placebo daily for 24 weeks, and 50 patients each received three different amounts of tesofensine. 161 patients completed the so-called phase II study, which included a diet.
Tesofensine Buy Online Range of Side Effects
Placebo patients had lost an average of two kilograms, those treated with tesofensine 7, 11 or 13 kilograms depending on the dose. This corresponds to a doubling of the weight loss compared to the active ingredients sibutramine and rimonabant, the researchers write. Side effects would have included nausea, constipation, insomnia, diarrhea and dry mouth.
Beware of addiction
There are particularly high safety requirements for medicines to combat obesity, explained Bischoff. So far, not a single agent that acts centrally in the brain like tesofensine has met these requirements. According to researchers, the active ingredient blocks the absorption of hunger-triggering neurotransmitters in the brain. “A lot of hopes have been awakened that have quickly leveled out.” For example, appetite suppressants attracted attention because of their addictive potential. “Rimonabant” triggers depression.
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The drug is still on the market, but after several suicides in the USA there are already discussions about its approval. For tesofensin, it is now necessary to wait for a further investigation (phase III study) with more patients before the suitability can be assessed. Tesofensine is not an active ingredient specially developed to combat obesity. It has so far been tested in Alzheimer’s and Parkinson’s patients. It had been shown that the patients lost weight as a result of ingestion.